The first, other than the lost Hungarian Drakula halála (1921), was Nosferatu (1922). Director F. M. Murnau changed the names and some of the details when he couldn't get the rights to the novel, but he kept the dread and disgust.
This is not the romantic figure in cape and tails who enthralls his victims with the hint of sexual ecstasy. The nosferatu is a monster who smells of rotting corpses and brings pestilence and death. To portray Count Orlok, Max Schreck drew on all of the anti-Semitic stereotypes common in the era, from the hooked nose and bushy eyebrows to the blood libel.
And on homophobia.
The next morning Gustav doesn't remember what happened, but he is filled with disgust.
Next Count Orlok sets his fangs on Ellen (Greta Schroeder), Hutter's wife, who has "a lovely neck." But when she gives herself willingly to him, he bursts into flame. This is perhaps the first time in history where a same-sex liaison increases one's vigor, but a heterosexual liaison is fatal.
Costume designer Albin (gay actor Udo Kier) and cinematographer Fritz (Cary Elwes) discover that Max Schreck really is a vampire, and Murnau knew it all along. Unfortunately, they are both killed before the vampire exploes. But at least Murnau got his movie.