1. The usual TGIF family was affluent, but the Connors were strictly working class. Dan (John Goodman) was a mechanic, and Roseanne (Roseanne Barr) worked in a factory and a hair salon before opening a "loose meat" restaurant.
2. The usual TGIF family was kid-dominated, with Dad to offer sage advice and Mom mostly irrelevant, but Roseanne was the undisputed head of the household.
3. The usual TGIF family was aggressively polite, at least to each other, but the Connors argued, fought, and traded insults (with the requisite undertow of affection, of course).
4. There was no teenage hunk; the Connor kids consisted of teenage girls Becky (Lecy Goranson, Sarah Chalke) and Darlene (Sarah Gilbert, left), and preteen boy DJ (Michael Fishman). Eventually Becky married Mark (Glenn Quinn), and the Connors adopted the shy, artistic David (Johnny Galecki, right), who began dating Darlene, but neither provided many beefcake shots.
5. There were gay people. Lots of them. And they weren't even living in Manhattan. Including one of the first bisexual characters on tv who wasn't evil or "confused": Roseanne's friend Nancy. Plus Leon Carp, Roseanne's uptight boss, and his partner (for whom Roseanne arranges a wedding, with drag legend Milton Berle as a guest).
Although Roseanne herself has come out as quite homophobic in her old age, many of her cast members have been involved with gay-positive projects. Glenn Quinn (right) played a gay-vague demon with a crush on the vampire detective Angel. Johnny Galecki played a gay character (with a full-frontal nude scene) in The Little Dog Laughed. John Goodman, who was rather homophobic as Dan, starred (briefly) as a gay man in Normal, Ohio. Sarah Gilbert came out as a lesbian in 2010.
Michael Fishman hasn't been involved in any gay-themed projects, but he has grown up into quite a hunk.